Sleep

I hope to revisit sleep and dreams at a later point, but here is a brief crack at providing something interesting before I delve into exam season, and is the first piece I have written particularly for the purposes of this blog! Enjoy.

Almost every single organism we know of, from bacteria to blue whales has a some manner of circadian rhythm, and all of those with a brain have some manner of equivalent to sleeping.

While the simplest explanation for why we must sleep is that we become sleepy, sleep deprivation is eventually 100% fatal. A study into sleep deprivation in rodents was conducted, and within two weeks, every single subject died. When autopsies were conducted, nothing was found to be obviously wrong, except for the tell-tale signs of not breathing and zero blood pressure, commonly found in things that are not alive.

But beyond this perhaps ethically troubling experiment, a rare condition exists in humans by the name of fatal familial insomnia. It will come as no surprise to the more attentive reader that this too is invariably fatal, and is a condition caused by prion buildup in the brain leading to progressive deterioration of the ability to sleep. Death usually follows within 7 to 36 months of the onset of symptoms, which progresses from a state of partial insomnia leading to panic attacks and hallucinations, to total insomnia leading to dementia and death.

What is sleep? I think of myself as a consciousness generated by my own neuroanatomy, so when I am unconscious, to an extent you could argue that I no longer exist. You could use an analogy with the image produced on a computer screen as the conscious awareness produced y the unknown workings of a humming desktop computer. The screen will go into standby after a while, but the overall hum of the computer will not disappear entirely.

The analogy, while perhaps already a strain, ought not be taken much further. Computer screens will turn themselves off to prevent ‘burn in’, and while an interesting case could be made to apply this analogy to the mind, the reality is that scientists are still struggling to provide a definitive reason for why we need to sleep, or indeed point to the mechanisms through which insomnia causes immune suppression, depression, and even death.

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Massive thank you to Mei Mac!!

Hello!

So this website was set up on my behalf by the apparently tech savy Mei Mac, without my knowledge, permission or consent.
That being said….

It’s so cool! I’d been urged in the past by friends to get into blogging, but in her infinite wisdom, she was aware that I’d never get round to it without a kick up the bum. Now that my bum is sufficiently kicked, I’m really looking forward to musing about consciousness, and I’ll also be sharing any thoughts I have about developments in the neuroscience world.

I’ll probably take a while to get into the swing of this blogging business on account of exam stuff, and I hope to buck up the standard of my writing for anyone who enjoys what I blab about. So watch this space.

Mei definitely got one thing right.
Brains are fucking cool.

Representation and Memory

Written ‘a while back’, by Barney Low

When I saw a firetruck for the first time in my wild and misspent toddlerhood, there is a good chance that it was driving along without the siren blaring and lights flashing, nor indeed with any flaming building with billowing smoke in sight. Now however, when I think of the word firetruck, my mind immediately leaps to such images, perhaps with some offshoots into subjectively related concepts such as firemen, the battery of my fire alarm, or the f***ers who set off the fire alarms at unholy hours during my stay in my university’s halls of residence.

With the specific example of the firetruck, prior to this encounter I had probably developed a fairly extensive neuronal representation of what a firetruck might be associated with, having been a huge fan of ‘Fireman Sam’ as a child. If you had spoken the word ‘firetruck’ to me before the first time I saw one in real life, the pre-existing neuronal network linked to the auditory stimuli of the word would probably have had a few synaptic connections with the word ‘Sam’ and the visual image of his stop motion figurine, others might connect with sections of the brain associated with excitement, or the vague notion of sitting down to watch television.

As the real life vehicle drove past me for the first time, the basic visual stimuli to enter my eyes would be of a large, red, rectangular version of a car, driving along a road. It seems likely that I would have asked my Mum or Dad to confirm my suspicions; that I could store these novel stimuli under the neurone labelled ‘firetruck’. For the first time, a raw sensory exposure to this object of interest to me would be networked in, with links made to the colour, size, noise, and vehicular nature of the firetruck. At this point I think it is necessary to try and explain how the networking of the brain allows us to recall, at will, the image, sound, taste, emotional significance or functionality of an idea or object, and how this ability is intrinsically linked to perhaps the most significant difference between other animals and man – language.

For the sake of simplicity, I will try to explain the recall of long term memory with the example of a visual stimuli, but arguably the same principles apply to all kinds of recall. The human brain contains a lot of neurones, with some of the more conservative estimates guessing at around 86 billion, and with each neurone synapsing with an average of 7000 other neurones. When presented with an object, for instance an old teddy bear, the raw data  of light-dependent depolarization in the retina undergoes a great deal of processing before it enters the conscious field. There will be individual neurones that fire for almost every conceivable visual detail of an object; some that fire off when presented with a humanoid shape, others that fire off when presented with the particular colour of the bear, or indeed a lump of colour of a particular size or shade. Others still might fire in response to the specific pattern of light and shade that reveals the furry texture of the bear’s fur, or indeed the recognisable shape of most eyes we are exposed to. This pattern of firing would be preserved by one of the hallmark phrases of neuroscience – “neurones that fire together, wire together”, where a group of representory neurones that happen to be interconnected with most if not all of the stimuli, would strengthen their synaptic links with all of the lower echelon neurones, like the roots of a single bud.

The first time we saw the bear, we may have only had the word ‘teddy bear’ under which to label our furry friend, but having settled on a name such as ‘Louis’ or (I wasn’t a particularly imaginative child) ‘Panda’, that word would then have links back to all the various neurones that code for the different traits of that particular teddy. With language, we need only think the name of our childhood toy, and, without the original stimulus of the teddy in front of us, the neurone representing it would simultaneously fire off all the different sensory stimuli that had been activated alongside it in the past, as well as the stored representations of the bear’s texture, and emotional and sentimental significance.

The beauty of this system is that it allows each lower echelon neurone to fire off for many different objects, ideas or thoughts. A neurone that codes for circular shapes might fire off in response to anything from an apple to a clock, and would even fire off (though slightly less exuberently) when presented with the raw sensory data for a pear, far more than it would in response to a sock or a firetruck. It is by matching profiles of the firing (and indeed the specific frequency of firing) of many hundreds or thousands of neurones to a select few, higher echelon neurones, linked with others coding for verbal labelling and other associations, that we are able to so easily resubject ourselves to past experiences, thoughts and sensations at will, in ways that other animals have shown little evidence of being capable of. It also explains why the representation of individual concepts or ideas seems so diffuse when inspected using imaging techniques such as fMRIs, with the many hundreds of traits that make them up being spread broadly around the various sections of the brain.

Consciousness

Written ‘A while back’, by Barney Low

This was written a while back to try and summarize and present some concepts I was introduced to by an fascinating book on consciousness (Going Inside, by John McCrone). Please feel free to comment or correct.

Each instant of consciousness is the result of intense competition between the firing of neurones representing different facets of our mind, with some representing long term memories, objectives and desires, others the raw sensory input of the moment, and others still continuing to fire from the previous instant of consciousness. The thought, sensation or emotion that is potentiated is selected based on the frequency of its firing and its synergy with others that fired along with it, with neurones that fire for the abstract concept of a tree being more likely to fire off when preceded with the firing of subjectively linked ideas, such as forests or nature.

When the victor of this competition is pain, such as when we tread on a pin whilst dancing in our pyjamas, that instant of consciousness will be dominated almost completely by a redirecting of awareness to the overriding stimulus: making us aware of the noxious stimuli, diverting our gaze to the source of the pain as reported by our proprioception, and alerting us to the fact that we have instinctively pulled our foot away.

If we are aware of incoming pain, such as when we are given an injection by a doctor, our mind is primed to suppress the reflex withdrawal and perhaps even anger that would normally result from the sensory stimuli we are subjected to. Here is an example of where the higher cognitive levels of the frontal lobes associated with planning might become involved, interacting and modulating the more primal and reflex orientated aspects of our brain’s functions in preparation for the instants to come. We might even be able to continue a stream of verbal or internal dialogue with our friendly doctor (or our disgruntled complaining self); ensuring by concentrating and the suppression of other input, that the chain of neuronal firing responsible for producing logical sentences is not interrupted from one instant to the next.

This continuity is an essential feature of our conscious experience, with our more recently active (or generated) neuronal networks firing off with greater frequency than less relevant neurones, which might for example represent our mind’s map of our primary school or the visual stimuli of a long lost toy. Examples of this continuity in action would be the continual firing of a neurone representing anything from the earlier content (or the general gist) of a friend’s tale as they expand into gory details, to recalling which seat at the dinner table is our own. This form of recall is essentially what is known as ‘working memory’, and I will go on to discuss how the brain might be able to potentiate the raw content of a moment in a more long term form in another spiel.

Published in Pi Magazine: The Stuff of Thought

Published in Pi Magazine: The Stuff of Thought

Published on 2nd March 2013 in Pi Magazine. It’s basically a rehash of the ‘Consciousness’ and ‘Representation and Memory’ spiels, so if you’ve seen them, then maybe give it a miss. Alternatively, if you’d prefer a condensed summary of the two, then go right ahead!

Click on the link above to read the article online.

The Stuff of Thought. By Barney Low

stuffofthought